硝酸 
中文同義詞: (2,4-二氯基)-2-[(2,4-二氯基)甲氧基]乙基]-1H-咪唑硝酸鹽;達(dá)克寧;美康唑;密康唑;雙氯咪唑;酶康唑;硝酸氯 
英文名稱: Miconazole nitrate 
英文同義詞: 1-[2,4-DICHLORO BETA-[2,4-DICHLOROBENZYL]OXY]-PHENETHYL]IMIDAZOLE NITRATE;1-[2,4-DICHLORO-BETA-([2,4-DICHLOROBENZYL]OXY)-PHENETHYL]IMIDAZOLE NITRATE SALT;1-[2-(2,4-DICHLOROBENZYLOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE;LABOTEST-BB LT00134678;(+/-)MICONAZOLE NITRATE SALT;1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-imidazolmononitra;1h-imidazole,1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl);daktacort 
CAS號(hào): 22832-87-7 
分子式: C18H15Cl4N3O4 
分子量: 479.14 
EINECS號(hào): 245-256-6 
相關(guān)類別: 原料藥;抗生素;抗菌，皮膚外用
性狀：該品為白色或類白色的結(jié)晶或結(jié)晶性粉末；無(wú)臭或幾乎無(wú)臭。該品在甲醇中略溶，在氯仿或中微溶，在水中不溶。    
標(biāo)準(zhǔn)：USP/BP 99%
用途：硝酸是人工合成的1-乙基咪唑衍生物，屬于咪唑類廣譜抗真菌藥物，就是我們熟悉的常用于治療皮膚癬的藥物達(dá)克寧，破壞細(xì)胞膜結(jié)構(gòu)，使細(xì)胞膜的通透性增大，導(dǎo)致細(xì)胞內(nèi)成份外泄并抑制葡萄糖的利用，阻止?fàn)I養(yǎng)物攝取，終使真菌細(xì)胞死亡，適用于治療體癬、股癬、手癬、足癬、花斑癬以及真菌性甲溝炎和由酵母菌（如念珠菌等）和革蘭氏陽(yáng)性細(xì)菌引起的陰道感染和繼發(fā)性感染,對(duì)外耳炎、細(xì)菌性皮膚感染也有效。
包裝：25KG紙板桶

Miconazole nitrate
Synonyms:1-[2,4-dichloro beta-[2,4-dichlorobenzyl]oxy]-phenethyl]imidazole nitrate;1-[2,4-dichloro-beta-([2,4-dichlorobenzyl]oxy)-phenethyl]imidazole nitrate salt;1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole nitrate;Labotest-bb lt00134678;(+/-)miconazole nitrate salt;1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-imidazolmononitra;1h-imidazole,1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl);Daktacort
Cas:22832-87-7
Mf:C18h15cl4n3o4
Mw:479.14
Einecs:245-256-6
Product categories:Antifungals;Antifungal;Aromatics;Heterocycles;
Pharmaceuticals;Monistat
Chemical Properties:White Solid 
Assay:99%
Usage:Antifungal (topical).  An antifungal agent that inhibits platelet cyclooxygenase.
Biological Activity:Antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. 
Packing:25kg/paper barrel


Test Items Specification Test Results
Appearance White or Almost white powder Complies
Identification IR Similar to standard Complies
Appearance of Solution The solution is clear and not more intensely cloured than reference solutions Complies
Solubility Very slightly soluble in water; soluble in methanol ; slightly soluble in alcohol Complies
Angle of optical rotation -0.1o～+0.1o Complies
Related Substances Each Impurity ≤0.25% 0.18%
Total Impurity ≤0.5% 0.25%
Melting Point 163～167℃ 164.5℃
Loss on Drying ≤0.5% 0.32%
Residue on Ignition ≤0.1% 0.01%

Assay (on dry basis) 98.0～102.0% 99.38%

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4、制度說(shuō)明

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